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This is a list of software used to simulate the material and energy balances of chemical process plants. Applications for this include design studies, engineering studies, design audits, debottlenecking studies, control system check-out, process simulation, dynamic simulation, operator training simulators, pipeline management systems, production management systems, digital twins.

Software	Developer	Applications	Operative system	License	URL
Advanced Simulation Library (ASL)	Avtech Scientific	Process data validation and reconciliation, real-time optimization, virtual sensing and predictive control	Windows, Linux, FreeBSD, Mac	open-source	[1]
APMonitor	APMonitor	Data reconciliation, real-time optimization, dynamic simulation and nonlinear predictive control	[2]
Apros	Fortum and VTT Technical Research Centre of Finland	Dynamic process simulation for power plants	Windows	Commercial	[3]
ASCEND	ASCEND	Dynamic process simulation, general purpose language	Windows, BSD, Linux	open-source	[4]
Aspen Custom Modeler (ACM)	Aspen Technology	Dynamic process simulation	Windows	Commercial	[5]
Aspen HYSYS	Aspen Technology	Process simulation and optimization	Windows	Commercial	[6]
Aspen Plus	Aspen Technology	Process simulation and optimization	Windows	Commercial	[7]
ASSETT	Kongsberg Digital	Dynamic process simulation	Windows	Commercial	[8]
BatchColumn	ProSim	Simulation and Optimization of batch distillation columns	Windows	commercial	[9]
BATCHES	Batch Process Technologies, Inc.	Simulation of recipe driven multiproduct and multipurpose batch processes for applications in design, scheduling and supply chain management	Linux	Commercial	[10]
BatchReactor	ProSim	Simulation of chemical reactors in batch mode	Windows	Commercial	[11]
BioSTEAM	Yoel Cortes-Pena & BioSTEAM Development Group	Design, simulation, and costing of biorefineries under uncertainty	Windows, Mac, Linux	open-source	[12]
CADSIM Plus	Aurel Systems Inc.	Steady-state and dynamic process simulation	Windows	Commercial	[13]
ChromWorks	YPSO-FACTO	Chromatographic process design, simulation & optimization	Windows	Commercial	[14]
CHEMCAD	Chemstations	Software suite for process simulation	Windows	Commercial	[15]
CHEMPRO	EPCON	Process Flow Simulation, Fluid Flow Simulation, & Process Equipment Sizing	Windows	Commercial	[16]
Clearview	Mapjects	Dynamic Asset BIM process simulation and optimization	Windows & Debian Linux
Cycad Process	CM Solutions	Process simulation and drawing package for minerals and metallurgical fields	Windows	Commercial, Free for academic use	[17]
Cycle-Tempo	Asimptote	Thermodynamic analysis and optimization of systems for the production of electricity, heat and refrigeration	[18]
COCO simulator + ChemSep	AmsterCHEM	Steady state process simulation based on CAPE-OPEN Interface Standard	Windows	Free
D-SPICE	Kongsberg Digital	Dynamic process simulation	Windows	Commercial
Design II for Windows	WinSim Inc.	Process simulation	[21]
Distillation expert trainer	ATR	Operator training simulator for distillation process	[22]
Dymola	Dassault Systèmes	Modelica-based dynamic modelling and simulation software	Windows, Linux	Commercial	[23]
DynoChem	Scale-up Systems	Dynamic process simulation and optimization	Windows	Commercial	[24]
DYNSIM	AVEVA	Dynamic process simulation	Windows	Commercial
DWSIM	Daniel Medeiros, Gustavo León and Gregor Reichert	Process simulator	Windows, Linux, macOS, Android, iOS	open-source (Windows/Linux/macOS), free + in-app purchases (Android/iOS)	[25]
EMSO	ALSOC Project	Modelling, simulation and optimisation, steady state and dynamic, equation oriented with open source models	Windows, Linux	ALSOC License
EQ-COMP	Amit Katyal	Vapor Liquid Equilibrium Software	SAAS	[59]
FlowTran	FlowTran	Transient single phase pipeline simulation	Commercial	[27]
GAMS	GAMS	General Algebraic Modeling System (GAMS)	Windows, Linux, Mac OS, Solaris	Commercial	[28]
gPROMS	PSE Ltd	Advanced process simulation and modelling	[29]
HSC Sim	Outotec Oyj	Advanced process simulation and modelling, Flowsheet simulation	Windows	[30]
HYD-PREDIC	Amit Katyal	Flow Assurance Software
HYDROFLO	Tahoe Design Software	Piping System Design with Steady State Analysis	Windows	Free Academic, Standard Commercial	[31]
Indiss Plus®	Corys	Dynamic process simulator for hydrocarbons, chemicals	[32]
ICAS	CAPEC	Integrated Computer-Aided System	[33]
IDEAS	Andritz Automation	Dynamic simulator for pulp, oil sands, potash, and hard rock mining	Windows	Commercial	[34]
iiSE Simulator	iiSE company	Equation oriented chemical process simulator and optimizer	Windows, Linux	Commercial	[35]
ITHACA	Element Process Technology	Dynamic chemical process simulator	Windows	[36]
JADE	GSE Systems	Dynamic process simulation	Windows	Commercial
JModelica.org	Modelon AB	Process simulation	Windows, Linux, Mac OS	open-source
K-Spice	Kongsberg Digital	Dynamic process simulation	Windows	Commercial	[37]
LedaFlow	Kongsberg Digital	Transient multiphase pipeline simulation	Windows	Commercial	[38]
LIBPF	simevo	C++ LIBrary for process flowsheeting
METSIM	Metsim International	General-purpose dynamic and steady state process simulation system	Windows	[39]
Mimic Simulation Software	MYNAH Technologies	First-prin

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